| Date | Location | Result | |
| 03/11/22 | Las Vegas, NV | Abilene Christian 78, Seattle U 76 | |
| 03/05/22 | Seattle, WA | Seattle U 74, Chicago St. 66 | |
| 02/26/22 | St. George, UT (Burns Arena) | Seattle U 73, Dixie St. 65 | |
| 02/24/22 | Orem, UT (UCCU Center) | Utah Valley 67, Seattle U 52 | Box score |
| 02/21/22 | Seattle, WA | New Mexico St. 68, Seattle U 55 | Box score |
| 02/19/22 | Seattle, WA (Climate Pledge Arena) | Seattle U 67, California Baptist 64 | Box score |
| 02/16/22 | Edinburg, TX (UTRGV Fieldhouse) | Seattle U 102, UTRGV 62 | Box score |
| 02/12/22 | Seattle, WA | Seattle U 76, Lamar University 50 | Box score |
| 02/10/22 | Seattle, WA | Seattle U 67, UTRGV 59 | Box score |
| 02/05/22 | Las Cruces, NM | New Mexico St. 79, Seattle U 64 | Box score |
| 02/03/22 | Phoenix, AZ | Grand Canyon 78, Seattle U 66 | Box score |
| 01/29/22 | Seattle, WA | Seattle U 78, Sam Houston 63 | Box score |
| 01/26/22 | Seattle, WA | Seattle U 70, SFA 62 | Box score |
| 01/22/22 | Stephenville, TX | Seattle U 76, Tarleton St. 68 | Box score |
| 01/20/22 | Abilene, TX | Seattle U 72, Abilene Christian 62 | Box score |
| 01/17/22 | Riverside, CA | Seattle U 92, California Baptist 85 (OT) | Box score |
| 01/15/22 | Seattle, WA | Seattle U 79, Utah Tech 68 | Box score |
| 01/12/22 | Seattle, WA | Seattle U 71, Utah Valley 65 | Box score |
| 01/06/22 | Chicago, IL | Seattle U 93, Chicago St. 77 | Box score |
| 12/22/21 | Seattle, WA | Seattle U 100, Northwest (WA) 68 | Box score |
| 12/18/21 | Seattle, WA | Washington 64, Seattle U 56 | Box score |
| 12/12/21 | Seattle, WA | Seattle U 73, UC San Diego 51 | Box score |
| 12/08/21 | Las Vegas, NV | UNLV 76, Seattle U 56 | Box score |
| 12/05/21 | Seattle, WA | VMI 89, Seattle U 82 | Box score |
| 12/01/21 | Seattle, WA | Seattle U 78, McNeese 62 | Box score |
| 11/27/21 | Seattle, WA | Seattle U 81, St. Thomas (MN) 64 | Box score |
| 11/23/21 | Seattle, WA | Seattle U 89, Pacific Lutheran 40 | Box score |
| 11/22/21 | Seattle, WA | Seattle U 77, Ark.-Pine Bluff 56 | Box score |
| 11/18/21 | Seattle, WA | Seattle U 93, Morgan St. 80 | Box score |
| 11/14/21 | Seattle, WA | Seattle U 77, Idaho St. 51 | Box score |
| 11/12/21 | Pullman, WA | Washington St. 79, Seattle U 61 | Box score |
| 11/10/21 | Seattle, WA | Seattle U 69, Alcorn 66 | Box score |